Contact Information
College of Medicine, UIUC
506 S. Mathews Ave
Urbana, IL 61801
Research Interests
Research Topics
Molecular Immunology
Research Description
Immunotherapy
We are committed to developing immunotherapies for brain tumors that are effective and selective. We use mice as experimental subjects because much is know about their immune system, and the murine system closely parallels the human immune system. When properly activated, the immune system has the characteristics of an ideal therapy: potent, precise killing of altered cells. But there is much to be learned about how to activate, direct, and control the immune response, particularly against tumors within the brain. We focus mostly on T cell mediated immune responses, and work in close collaboration with the laboratory of David Kranz, a T cell biochemist.
Education
B.A. 1970 Brown University
Ph.D. 1976 University of Massachusetts
Postdoc. 1976-1979 The Rockefeller University
Additional Campus Affiliations
Affiliate, Carl R. Woese Institute for Genomic Biology
Department Affiliate, Molecular and Integrative Physiology
Recent Publications
Lichtor, T., Tang, B., & Roy, E. J. (2023). Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor. Brain Sciences, 13(11). https://doi.org/10.3390/brainsci13111505
Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J., & Kranz, D. M. (2023). Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. Journal for ImmunoTherapy of Cancer, 11(5), Article e006509. https://doi.org/10.1136/jitc-2022-006509
Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2021). A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine, 13(603), Article eabf1383. https://doi.org/10.1126/scitranslmed.abf1383
Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J., & Roy, E. J. (2020). Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma. Clinical Cancer Research, 26(9), 2216-2230. https://doi.org/10.1158/1078-0432.CCR-18-3626
Tang, B., Guo, Z. S., Bartlett, D. L., Liu, J., McFadden, G., Shisler, J. L., & Roy, E. J. (2019). A Cautionary Note on the Selectivity of Oncolytic Poxviruses. Oncolytic virotherapy, 8, 3-8. https://doi.org/10.2147/OV.S189832